Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …

Aberrant c‐Met activity has been implicated in the development of hepatocellular carcinoma
(HCC), suggesting that c‐Met inhibition may have therapeutic potential. However, clinical …

The liver is one of the most studied organs of the human body owing to its central role in
xenobiotic and drug metabolism. In recent decades, extensive research has aimed at …

Cholangiopathies, such as primary sclerosing cholangitis, biliary atresia, and
cholangiocarcinoma, have limited experimental models. Not only cholangiocytes but also …

Primary sclerosing cholangitis (PSC) is a heterogeneous and progressive fibroinflammatory
cholangiopathy with no known etiology or effective treatment. Studies of PSC are limited due …

Cellular senescence is an irreversible cell cycle arrest implemented by the cell as a result of
stressful insults. Characterized by phenotypic alterations, including secretome changes and …

Cholangiocytes are the target of a group of chronic liver diseases termed the
“cholangiopathies,” in which cholangiocytes react to exogenous and endogenous insults …

The aging process is represented by the time‐dependent decay in physiologic functions of
living beings. Major interest has been focused in recent years on the determinants of this …

Background & Aims Biliary disease is associated with a proliferative/fibrogenic ductular
reaction (DR). p300 is an epigenetic regulator that acetylates lysine 27 on histone 3 …