Covering: 2000 to January 2023 Diabetes is a metabolic disease of serious concern
nowadays, with a negative economic impact. In 2021, the International Diabetes Federation …

Allostery is the most direct and efficient way for regulation of biological macromolecule
function, ranging from the control of metabolic mechanisms to signal transduction pathways …

Carbohydrates present a special set of challenges to the generation of force fields. First, the
tertiary structures of monosaccharides are complex merely by virtue of their exceptionally …

The actin fold is found in cytoskeletal polymers, chaperones, and various metabolic
enzymes. Many actin-fold proteins, such as the carbohydrate kinases, do not polymerize. We …

Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency
and protein modification. Recent findings uncovered the allosteric function of ATP in cellular …

As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is
an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved …

Glucokinase (GK) catalyses the formation of glucose 6-phosphate from glucose and ATP. A
specific feature of GK amongst hexokinases is that it can cycle between active and inactive …

Carbohydrate kinases activate a wide variety of monosaccharides by adding a phosphate
group, usually from ATP. This modification is fundamental to saccharide utilization, and it is …

Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose
sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in the liver …

Abstract Aims/Introduction To investigate the clinical and genetic characteristics of Chinese
patients with a phenotype consistent with maturity‐onset diabetes of the young type 2 and …