Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

The kidney harbours different types of endothelia, each with specific structural and functional
characteristics. The glomerular endothelium, which is highly fenestrated and covered by a …

BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

The function of the kidney, filtering blood and concentrating metabolic waste into urine, takes
place in an intricate and functionally elegant structure called the renal glomerulus. Normal …

Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …

Pericytes are a heterogeneous population of cells located in the blood vessel wall. They
were first identified in the 19th century by Rouget, however their biological role and potential …

Diabetic kidney disease (DKD) remains a leading cause of new-onset end-stage renal
disease (ESRD), and yet, at present, the treatment is still very limited. A better understanding …

Lipidomics aims to quantitatively define lipid classes, including their molecular species, in
biological systems. Lipidomics has experienced rapid progress, mainly because of …

The architectural design of our kidneys is amazingly complex, and culminates in the 3D
structure of the glomerular filter. During filtration, plasma passes through a sieve consisting …

Diabetic nephropathy is the major cause of end‐stage renal failure throughout the world in
both developed and developing countries. Diabetes affects all cell types of the kidney …