Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease

L Jia, J Piña-Crespo, Y Li - Molecular brain, 2019 - Springer
Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

The therapeutic potential of neurofibromin signaling pathways and binding partners

J Báez-Flores, M Rodríguez-Martín, J Lacal - Communications Biology, 2023 - nature.com
Neurofibromin controls many cell processes, such as growth, learning, and memory. If
neurofibromin is not working properly, it can lead to health problems, including issues with …

[HTML][HTML] Cannabis sativa and cannabidiol: a therapeutic strategy for the treatment of neurodegenerative diseases?

MB Viana, PEA Aquino, D Estadella… - Medical Cannabis and …, 2022 - karger.com
This work is a literature review, presenting the current state of the use of cannabinoids on
neurodegenerative diseases. The emphasis is on Parkinson's (PD) and Alzheimer's (AD) …

Dysregulated Wnt signalling in the Alzheimer's brain

ND Aghaizu, H Jin, PJ Whiting - Brain Sciences, 2020 - mdpi.com
The Wnt signalling system is essential for both the developing and adult central nervous
system. It regulates numerous cellular functions ranging from neurogenesis to blood brain …

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease

ME Jones, J Büchler, T Dufor, E Palomer, S Teo… - Science …, 2023 - science.org
Synapse loss strongly correlates with cognitive decline in Alzheimer's disease (AD), but the
underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to …

Alzheimer's disease and protein kinases

AB Engin, A Engin - Protein Kinase-mediated Decisions Between Life and …, 2021 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder and accounts for
more than 60–80% of all cases of dementia. Loss of pyramidal neurons, extracellular …

Novel contribution of secreted amyloid-β precursor protein to white matter brain enlargement in autism spectrum disorder

DK Sokol, B Maloney, CJ Westmark… - Frontiers in psychiatry, 2019 - frontiersin.org
The most replicated neuroanatomical finding in autism is the tendency toward brain
overgrowth, especially in younger children. Research shows that both gray and white matter …

[HTML][HTML] Unveiling the potential of Phytocannabinoids: exploring Marijuana's lesser-known constituents for neurological disorders

BS Basavarajappa, S Subbanna - Biomolecules, 2024 - mdpi.com
Cannabis sativa is known for producing over 120 distinct phytocannabinoids, with Δ9-
tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) being the most prominent, primarily …

APPlications of amyloid-β precursor protein metabolites in macrocephaly and autism spectrum disorder

DK Sokol, DK Lahiri - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Metabolites of the Amyloid-β precursor protein (APP) proteolysis may underlie brain
overgrowth in Autism Spectrum Disorder (ASD). We have found elevated APP metabolites …

Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved

R Coronel, C Palmer… - Neural regeneration …, 2019 - journals.lww.com
The pathological implication of amyloid precursor protein (APP) in Alzheimer's disease has
been widely documented due to its involvement in the generation of amyloid-β peptide …