How aging affects cells of the human brain active milieu remains largely unknown. Here, we
analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and older …

Cerebral small vessel disease (cSVD) encompasses a heterogeneous group of age-related
small vessel pathologies that affect multiple regions. Disease manifestations range from …

Skeletal muscle is a highly specialized tissue composed of myofibres that performs crucial
functions in movement and metabolism. In response to external stimuli and injuries, a range …

Aging is a major risk factor for cognitive impairment. Aerobic exercise benefits brain function
and may promote cognitive health in older adults. However, underlying biological …

Aging is frequently associated with compromised cerebrovasculature and pericytes.
However, we do not know how normal aging differentially impacts vascular structure and …

Introduction Dysfunction of the cerebral vasculature is considered one of the key
components of Alzheimer's disease (AD), but the mechanisms affecting individual brain …

In the brain, a microvascular sensory web coordinates oxygen delivery to regions of
neuronal activity. This involves a dense network of capillaries that send conductive signals …

The close spatial relationship between microglia and cerebral blood vessels implicates
microglia in vascular development, homeostasis and disease. In this study we used the …

During neuronal activity, cerebral blood flow increases to ensure adequate glucose and
oxygen supply, a crucial mechanism known as the neurovascular coupling response. Blood …

Objectives: Previous studies indicate region-specific age-and sex-related changes in
cerebral microvasculature. Using whole-brain vascular architecture mapping (VAM), our …