Most bacteria are surrounded by a peptidoglycan cell wall that defines their shape and
protects them from osmotic lysis. The expansion and division of this structure therefore plays …

The peptidoglycan (PG) cell wall is an extra-cytoplasmic glycopeptide polymeric structure
that protects bacteria from osmotic lysis and determines cellular shape. Since the cell wall …

The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria. For
decades, it was thought that only class A penicillin-binding proteins (PBPs) and related …

Elongation of rod-shaped bacteria is mediated by a dynamic peptidoglycan-synthetizing
machinery called the Rod complex. Here we report that, in Bacillus subtilis, this complex is …

Multi-protein complexes organized by cytoskeletal proteins are essential for cell wall
biogenesis in most bacteria. Current models of the wall assembly mechanism assume that …

Penicillin-binding proteins (PBPs) have been scrutinized for over 40 years. Recent structural
information on PBPs together with the ongoing long-term biochemical experimental …

Bacterial species have long been classified on the basis of their characteristic cell shapes.
Despite intensive research, the molecular mechanisms underlying the generation and …

Bacteria can respond to adverse environmental conditions by drastically reducing or even
ceasing metabolic activity. They must then determine that conditions have improved before …

The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

The bacterial cell wall is a highly conserved essential component of most bacterial groups. It
is the target for our most frequently used antibiotics and provides important small molecules …