Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however …

Up to now, little is known about the metabolic pathways of new fentanyl analogs that have
recently emerged on the drug markets worldwide with high potential for producing addiction …

The only drugs currently approved for the treatment of Alzheimer's Disease (AD) are four
acetylcholinesterase inhibitors and the NMDA antagonist memantine. Apart from these …

Chronic diseases are a significant healthcare problem. Partial or complete non-
responsiveness to chronic therapies is a significant obstacle to maintaining the long-term …

Background In response to the opioid epidemic and new guidelines, many patients on high-
dose long term opioid therapy (LTOT) for chronic pain are getting tapered off opioids. As a …

Alcohol abuse is a leading risk factor for the public health burden worldwide. Approved
pharmacotherapies have demonstrated limited effectiveness over the last few decades in …

Recommended treatment for attention deficit hyperactivity disorder (ADHD) includes
stimulant medication. While these medicines are effective for most ADHD patients, benefits …

The re-emergence (ie 'breakthrough') of depressive symptoms despite maintenance
treatment of depression with antidepressant drugs is a complex clinical phenomenon …

The dramatic expansion of internet communication tools has led to the increased use of
temporary online groups to solve problems, provide services, or produce new knowledge …

A recent article identified five key technical determinants that make substantial contributions
to the outcome of drug R&D projects (Lessons learned from the fate of AstraZeneca's drug …