Opioid analgesics are the standards of care for the treatment of moderate to severe
nociceptive pain, particularly in the setting of cancer and surgery. Their analgesic properties …

Background: Although a number of studies have investigated the association of the OPRM1
A118G polymorphism with pain response, a consensus has not yet been reached. Methods …

Background: Individual response to opioid analgesics varies among patients. Objective: This
study sought to clarify the impact of distinct genetic variations on pain, opioid consumption …

Recent pharmacogenomic/pharmacogenetic (PGx) studies have disclosed important roles
for drug transporters in the human body. Changes in the functions of drug transporters due …

Oxycodone, a semisynthetic derivative of naturally occurring thebaine, an opioid alkaloid,
has been available for more than 100 years. Although thebaine cannot be used …

Background Postsurgical pain is a key component of surgical recovery. However, the
genetic drivers of postsurgical pain remain unclear. A broad review and meta-analyses of …

Pharmacogenetic research has the potential to explain the variation in treatment efficacy
within patient populations. Understanding the interaction between genetic variation and …

The 118A> G single nucleotide polymorphism (SNP) in the μ-opioid receptor (OPRM1) gene
has been the most described variant in pharmacogenetic studies regarding opioid drugs …

Inadequate pain relief and adverse effects from analgesics remain common in children and
adults during the perioperative period. Opioids are the most commonly used analgesics in …

Oxycodone is a semisynthetic μ-and κ-opioid receptor with agonist with a broad scope of
use including postoperative analgesia as well as control of neuropathic and cancer pain …