Molecular simulations are promising tools for in silico design of drug delivery formulations,
as they provide a prediction of formulation properties prior to synthesis thus minimizing the …

Common energy-intensive processes applied in oral solid dosage development, such as
milling, sieving, blending, compaction, etc. generate particles with surface and bulk crystal …

At present, how the release kinetics of permeation enhancers affected their enhancement
efficacy on drug skin absorption and its molecular mechanisms remained unclear. Herein …

Molecular dynamics (MD) simulations have been conducted using an assembly consisting
of 105 indomethacin (IMC) molecules and 12 water molecules to investigate the underlying …

The differences between internal and external plasticization as well as how the molecular
structure of a plasticizer effects the glass transition temperature, T g, of a (meth) acrylate …

Scale-up of tableting process is particularly difficult due to specific concerns related
exclusively to the process itself and that cannot be determined on a smaller scale, which are …

ABSTRACT Introduction Dry Powder Inhalers (DPIs) continue to be developed to deliver an
expanding range of drugs to treat an ever-increasing range of medical conditions; with each …

MIL-100 (Fe) was synthesized under biofriendly conditions at room temperature and
pressure using iron (II) chloride as the source of iron, and it was coated with chitosan (CS), a …

The effects of propellant type, cosolvent content, and air humidity on the morphology and
solid phase of the particles produced from solution pressurized metered dose inhalers …

A series of semi-empirical equations were utilised to design two solution based pressurised
metered dose inhaler (pMDI) formulations, with equivalent aerosol performance but different …