Background Internet-and mobile-based interventions (IMIs) targeting depression have been
shown to be clinically effective and are considered a cost-effective complement to …

Background Valproate is a first-line treatment for patients with newly diagnosed idiopathic
generalised or difficult to classify epilepsy, but not for women of child-bearing potential …

Background Automated delivery of psychological therapy using immersive technologies
such as virtual reality (VR) might greatly increase the availability of effective help for patients …

Objectives To identify variables that predict health service utilisation (HSU) by adults with
mental disorders in the UK, and to determine the evidence level for these predictors. Design …

Background In view of the high co-occurrence of depression and insomnia, a novel way to
reduce the risk of escalating depression might be to offer an insomnia intervention. We …

Background Insomnia is prevalent and distressing but access to the first-line treatment,
cognitive behavioural therapy (CBT), is extremely limited. We aimed to assess the clinical …

Background Worry might be a contributory causal factor in the occurrence of persecutory
delusions in patients with psychotic disorders. Therefore we postulated that reducing worry …

This pragmatic randomized controlled trial tested the effectiveness of long‐term
psychoanalytic psychotherapy (LTPP) as an adjunct to treatment‐as‐usual according to UK …

Background Multimorbidity is not uncommon and the associated impact it places on
healthcare utilisation and societal costs is of increased concern. The aim of the current study …

Background Sleep disturbance occurs in most patients with delusions or hallucinations and
should be treated as a clinical problem in its own right. However, cognitive behavioural …