[HTML][HTML] Normal‑tension glaucoma: Pathogenesis and genetics

A Trivli, I Koliarakis, C Terzidou… - Experimental and …, 2019 - spandidos-publications.com
Normal‑tension glaucoma (NTG) is a multifactorial optic neuropathy which, similar to open‑
angle glaucomas, is characterized by progressive retinal ganglion cell death and …

Mendelian genes in primary open angle glaucoma

NC Sears, EA Boese, MA Miller, JH Fingert - Experimental eye research, 2019 - Elsevier
Mutations in each of three genes, myocilin (MYOC), optineurin (OPTN), and TANK binding
kinase 1 (TBK1), may cause primary open-angle glaucoma (POAG) that is inherited as a …

The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

MS Shim, A Nettesheim, J Hirt, PB Liton - Autophagy, 2020 - Taylor & Francis
The trabecular meshwork (TM) is a key regulatory tissue of intraocular pressure (IOP) in the
anterior chamber of eye. Dysfunction of the TM causes resistance to outflow of aqueous …

Genomic and transcriptomic characterization of papillary microcarcinomas with lateral neck lymph node metastases

D Perera, R Ghossein, N Camacho… - The Journal of …, 2019 - academic.oup.com
Abstract Context Most papillary microcarcinomas (PMCs) are indolent and subclinical.
However, as many as 10% can present with clinically significant nodal metastases …

[HTML][HTML] Hypertension in African populations: review and computational insights

SE Mabhida, L Mashatola, M Kaur, JR Sharma… - Genes, 2021 - mdpi.com
Hypertension (HTN) is a persistent public health problem affecting approximately 1.3 billion
individuals globally. Treatment-resistant hypertension (TRH) is defined as high blood …

[HTML][HTML] Research progress on human genes involved in the pathogenesis of glaucoma

HW Wang, P Sun, Y Chen… - Molecular …, 2018 - spandidos-publications.com
Glaucoma is the leading cause of irreversible blindness globally. It is known that the
incidence of glaucoma is closely associated with inheritance. A large number of studies …

[HTML][HTML] Biochemical–molecular–genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients

MD Pinazo-Durán, V Zanón-Moreno… - Frontiers in …, 2023 - frontiersin.org
Glaucoma is a chronic neurodegenerative disease accounting for the first irreversible cause
of blindness worldwide. Clinical and molecular glaucoma biomarkers indicate the biological …

Insights into the regulatory molecules involved in glaucoma pathogenesis

H Moazzeni, M Khani, E Elahi - American Journal of Medical …, 2020 - Wiley Online Library
Glaucoma is an important cause of irreversible blindness, characterized by optic nerve
anomalies. Increased intraocular pressure (IOP) and aging are major risk factors. Retinal …

[HTML][HTML] The genetic and endoplasmic reticulum-mediated molecular mechanisms of primary open-angle glaucoma

W Rozpędek-Kamińska, R Wojtczak, JP Szaflik… - International Journal of …, 2020 - mdpi.com
Glaucoma is a heterogenous, chronic, progressive group of eye diseases, which results in
irreversible loss of vision. There are several types of glaucoma, whereas the primary open …

[HTML][HTML] Ibrutinib in gynecological malignancies and breast cancer: a systematic review

JM Metzler, L Burla, D Fink, P Imesch - International journal of molecular …, 2020 - mdpi.com
Ibrutinib is an orally available, small-molecule tyrosine kinase inhibitor. Its main purpose is
to inhibit Bruton's tyrosine kinase (BTK), an enzyme that is crucial in B cell development. It is …