Pituitary tumor-transforming gene-1 (PTTG1) is overexpressed in a variety of endocrine-
related tumors, especially pituitary, thyroid, breast, ovarian, and uterine tumors, as well as …

One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which
is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged …

Cellular senescence is a form of irreversible growth arrest that cancer cells evade. The cell
division cycle protein 20 homolog (Cdc20) is a positive regulator of cell division, but how its …

Ensuring precise DNA replication and chromosome segregation is essential during cell
division in order to provide genomic stability and avoid malignant growth. Proteolytic control …

The cohesin protein complex holds sister chromatids together after synthesis until mitosis. It
also contributes to post-replicative DNA repair in yeast and higher eukaryotes and …

Transcription is arrested in the bovine oocyte within the first few hours of in vitro maturation,
thus the stored maternal mRNAs accumulated in the oocyte are essential to sustain …

Pituitary tumor-transforming gene (PTTG), a securin protein isolated from pituitary tumor cell
lines, is highly expressed in invasive tumors and exhibits characteristics of a transforming …

Abstract Cyclin-dependent kinase 1 (CDK1) is the central mammalian regulator of cell
proliferation and a promising therapeutic target for breast cancer. In fact, CDK1 inhibition …

The pituitary tumor-transforming gene (PTTG1) encodes a multifunctional protein (PTTG)
that is overexpressed in numerous tumours, including pituitary, thyroid, breast and ovarian …

Genetic instability (GI) is a hallmark feature of tumor development. Securin, also known as
pituitary tumor transforming gene (PTTG), is a mitotic checkpoint protein which is highly …