Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …

The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …

Misfolding and aggregation of disease-specific proteins, resulting in the formation of
filamentous cellular inclusions, is a hallmark of neurodegenerative disease with …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …

Lysosomes are in the center of the cellular control of catabolic and anabolic processes.
These membrane-surrounded acidic organelles contain around 70 hydrolases, 200 …

Genetic variation at the transmembrane protein 106B gene (TMEM106B) has been linked to
risk of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) through an …

Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos,
which is essential for neuron function and survival. Deficits in lysosome function result in …

Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …