The extracellular nucleoside adenosine reduces tissue inflammation and is generated by
irreversible dephosphorylation of adenosine monophosphate (AMP) mediated by the …

The tumor microenvironment (TME) is a complex and variable region characterized by
hypoxia, low pH, high redox status, overexpression of enzymes, and high‐adenosine …

Purinergic signalling, consisting of extracellular purines and purinergic receptors, modulates
cell proliferation, invasion and immunological reaction during cancer progression. Here, we …

Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with
temozolomide is the standard treatment, but nevertheless, relapse occurs in nearly all cases …

Treatment options for patients with NRAS-mutant melanoma are limited and lack an efficient
targeted drug combination that significantly increases overall and progression-free survival …

Nucleotides are released from all cells through regulated pathways or as a result of plasma
membrane damage or cell death. Outside the cell, nucleotides act as signalling molecules …

Ovarian cancer is a common gynecological malignancy, and its treatment remains
challenging. Although ovarian cancer may respond to immunotherapy because of …

Background Our previous study identified elevated expression of the P2X7 receptor
(P2X7R) in colorectal cancer (CRC) patients, suggesting the receptor is a target for …

Hyperinflammation plays an important role in severe and critical COVID-19. Using
inconsistent criteria, many researchers define hyperinflammation as a form of very severe …

Expression of the purinergic receptor P2RX7 by CD8+ T cells promotes the generation of
memory populations following acute infections. However, data suggest that P2RX7 may limit …