Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia
and hypoxia. Despite severe ischemia/hypoxia induces the occurrence and development of …

Symptomatic intracranial arterial stenosis (SIAS) is very common in octo-and
nonagenarians, especially in the Chinese population, and is likely the most common cause …

Searching for effective therapeutic agents‏‎ to‎‏ prevent‏‏ neurodegeneration‎ is a challenging
task due‎ to‎ the growing list of neurodegenerative disorders associated with a multitude of …

Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI)
encountered, particularly amongst elderly patients with clinical scenarios, such as age …

Objective Whether activation or inhibition of the mTOR pathway is beneficial to ischemic
injury remains controversial. It may result from the different reaction of ischemic penumbra …

Context Metformin induced AMP-activated protein kinase (AMPK) and protected neurons in
cerebral ischaemia. Objective This study examined pretreatment with metformin and …

Neurodegenerative disorders affect more than 30 million individuals throughout the world
and lead to significant disability as well as death. These statistics will increase almost …

Non-communicable diseases (NCDs) are medical conditions that, by definition, are non-
infectious and non-transmissible among people. Much of current NCDs are generally due to …