The proper functioning of the endoplasmic reticulum (ER) is crucial for multiple cellular
activities and survival. Disturbances in the normal ER functions lead to the accumulation and …

Neurodegenerative diseases are a large class of neurological disorders characterized by
progressive dysfunction and death of neurones. Examples include Alzheimer's disease …

Acute exposure to high concentrations of hydrogen sulfide (H2S) leads to sudden death
and, if survived, lingering neurological disorders. Clinical signs include seizures, loss of …

Glutamate-induced excitotoxicity is a major contributor to motor neuron degeneration in the
pathogenesis of amyotrophic lateral sclerosis (ALS). The spinal cord× Neuroblastoma hybrid …

The mitochondrial anchor syntaphilin (SNPH) is a key mitochondrial protein normally
expressed in axons to maintain neuronal health by positioning mitochondria along axons for …

It has been demonstrated that neuronal cells cultured on traditional flat surfaces may exhibit
exaggerated voltage gated calcium channel (VGCC) functionality. To gain a better …

It is well established that motor neurons are highly vulnerable to glutamate induced
excitotoxicity. The selective vulnerability of these neurons has been attributed to AMPA …

Abstract α motor neurons (MNs) are a target of the environmental neurotoxicant
methylmercury (MeHg), accumulating MeHg and subsequently degenerating. In mouse …

Imipramine, a major antidepressant, is known to inhibit reuptake of serotonin and
norepinephrine, which contributes to recovery from major depressive disorder. It has …

This hypothesis proposes that increased extracellular glutamate in Amyotrophic Lateral
Sclerosis (ALS) and cerebral ischemia, currently viewed as a trigger for excitotoxicity, is …