Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global
mortality, with three million deaths reported annually. This impact is expected to increase …

Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins,
S100A8 and S100A9. It is a multifunctional protein expressed mainly by neutrophils and …

Introduction Tobacco smoking generates airway inflammation in chronic obstructive
pulmonary disease (COPD), and its involvement in the development of lung cancer is still …

Systemic inflammation is established as part of late-stage severe lung disease, but
molecular, functional, and phenotypic changes in peripheral immune cells in early disease …

Lung diseases develop when telomeres shorten beyond a critical point. We constructed a
mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive …

Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, smoking-
related disease of significant global impact. The complex biology of COPD is ultimately …

The S100 protein family consists of over 20 members in humans that are involved in many
intracellular and extracellular processes, including proliferation, differentiation, apoptosis …

Chronic obstructive pulmonary disease (COPD) is a leading cause of global death. As a
molecule beyond adhesion, CD146 is involved in COPD pathogenesis. However, the …

Mycobacterium tuberculosis (M. tb) effectively manipulates the host processes to establish
the deadly respiratory disease, Tuberculosis (TB). M. tb has developed key mechanisms to …

Chronic obstructive pulmonary disease (COPD) is characterized by increased cellular stress
and inflammation. Heat shock protein 60 (HSP60) is a highly conserved stress protein that …