Prostacyclin released by cancer-associated fibroblasts promotes immunosuppressive and pro-metastatic macrophage polarization in the ovarian cancer …

L Sommerfeld, I Knuth, F Finkernagel, J Pesek… - Cancers, 2022 - mdpi.com
Simple Summary Reciprocal interactions between tumor and host cells in the tumor
microenvironment critically influence the clinical outcome in ovarian carcinoma patients …

Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology

C Ortiz-Placín, A Castillejo-Rufo, M Estarás… - Molecules, 2023 - mdpi.com
One of the most important constituents of the cell membrane is arachidonic acid. Lipids
forming part of the cellular membrane can be metabolized in a variety of cellular types of the …

PTGES expression is associated with metabolic and immune reprogramming in pancreatic ductal adenocarcinoma

D Murthy, KS Attri - International Journal of Molecular Sciences, 2023 - mdpi.com
Metabolic reprogramming is an established hallmark of multiple cancers, including
pancreatic cancer. Dysregulated metabolism is utilized by cancer cells for tumor …

[HTML][HTML] 2022 年度胰腺癌研究及诊疗新进展

王旭, 程合, 刘辰, 虞先濬 - 中国癌症杂志, 2023 - china-oncology.com
胰腺癌是中国致死人数排名第六的恶性肿瘤, 其恶性程度高, 早期病情隐匿, 超过80%
的患者在就诊时已进展为晚期, 错失手术切除治愈的机会; 而成功接受了手术治疗的胰腺癌患者 …

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

MS Dahabieh, LM DeCamp, BM Oswald… - bioRxiv, 2024 - biorxiv.org
The progressive decline of CD8 T cell effector function, also known as terminal exhaustion,
is a major contributor to immune evasion in cancer. Yet, the molecular mechanisms that …

New progress in basic research, clinical diagnosis and treatment of pancreatic cancer in 2022

W Xu, C He, LIU Chen, YU Xianjun - China Oncology, 2023 - china-oncology.com
Pancreatic cancer is the sixth leading cause of cancer-related death in China. It is
characterized by high malignancy and concealment at early stages. More than 80% of …