Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

E Parra, J Pérez-Gil - Chemistry and physics of lipids, 2015 - Elsevier
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

Respiratory fluid mechanics and transport processes

JB Grotberg - Annual review of biomedical engineering, 2001 - annualreviews.org
▪ Abstract The field of respiratory flow and transport has experienced significant research
activity over the past several years. Important contributions to the knowledge base come …

Computational lung modelling in respiratory medicine

S Neelakantan, Y Xin, DP Gaver… - Journal of The …, 2022 - royalsocietypublishing.org
Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …

[图书][B] Interfacial convection in multilayer systems

A Nepomnyashchy, JC Legros, I Simanovskii - 2006 - Springer
The interfacial convection in multilayer systems is a widespread phenomenon that is of great
importance in numerous branches of technology, including chemical engineering, space …

The POOR Get POORer: a hypothesis for the pathogenesis of ventilator-induced lung injury

DP Gaver III, GF Nieman, LA Gatto… - American journal of …, 2020 - atsjournals.org
Protective ventilation strategies for the injured lung currently revolve around the use of low
Vt, ostensibly to avoid volutrauma, together with positive end-expiratory pressure to increase …

[HTML][HTML] Effects of lung surfactant proteins, SP-B and SP-C, and palmitic acid on monolayer stability

J Ding, DY Takamoto, A Von Nahmen, MM Lipp… - Biophysical journal, 2001 - cell.com
Langmuir isotherms and fluorescence and atomic force microscopy images of synthetic
model lung surfactants were used to determine the influence of palmitic acid and synthetic …

Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening

SS Kay, AM Bilek, KC Dee… - Journal of Applied …, 2004 - journals.physiology.org
The reduction of tidal volume during mechanical ventilation has been shown to reduce
mortality of patients with acute respiratory distress syndrome, but epithelial cell injury can …

The biophysical function of pulmonary surfactant

S Rugonyi, SC Biswas, SB Hall - Respiratory physiology & neurobiology, 2008 - Elsevier
Pulmonary surfactant lowers surface tension in the lungs. Physiological studies indicate two
key aspects of this function: that the surfactant film forms rapidly; and that when compressed …

Biomechanics of liquid–epithelium interactions in pulmonary airways

SN Ghadiali, DP Gaver - Respiratory physiology & neurobiology, 2008 - Elsevier
The delicate structure of the lung epithelium makes it susceptible to surface tension induced
injury. For example, the cyclic reopening of collapsed and/or fluid-filled airways during the …

The steady propagation of a surfactant-laden liquid plug in a two-dimensional channel

H Fujioka, JB Grotberg - Physics of Fluids, 2005 - pubs.aip.org
In this study, we investigate the steady propagation of a liquid plug in a two-dimensional
channel lined by a uniform, thin liquid film. The liquid contains soluble surfactant that can …