(CVD) in individuals with type 1 diabetes mellitus (T1DM), the pathophysiology underlying
the relationship between cardiovascular events, CVD risk factors, and T1DM is not well …

Naturally arising CD25+ CD4+ regulatory T (Treg) cells, most of which are produced by the
normal thymus as a functionally mature T‐cell subpopulation, play key roles in the …

Immune-related adverse events, particularly severe toxicities such as myocarditis, are major
challenges to the utility of immune checkpoint inhibitors (ICIs) in anticancer therapy. The …

Immune-checkpoint inhibitors (ICIs) have revolutionized oncology, with nearly 50% of all
patients with cancer eligible for treatment with ICIs. However, patients on ICI therapy are at …

Myocarditis is defined as an inflammation of the cardiac muscle. In humans, various
infectious and non-infectious triggers induce myocarditis with a broad spectrum of …

Autoimmunity has long been linked to myocarditis and its sequela, dilated cardiomyopathy,
the leading causes of heart failure in young patients. However, the underlying mechanisms …

Myocarditis is defined by an immune response to infection or injury, most commonly
identified after a viral infection or recent exposure to cardiotoxins or drugs. Classic …

Abstract MRL/MpJ-Fas lpr (MRL-Fas lpr) mice develop a spontaneous T cell and
macrophage-dependent autoimmune disease that shares features with human lupus …

Cardiomyopathies are heart muscle diseases, which have been defined by their central
hemodynamics and macropathology and divided in five major forms: dilated (DCM) …

Myocarditis is a potentially lethal inflammatory heart disease of children and young adults
that frequently leads to dilated cardiomyopathy (DCM). Since diagnostic procedures and …