The median-effect equation derived from the mass-action law principle at equilibrium-steady
state via mathematical induction and deduction for different reaction sequences and …

The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic
myeloid leukemia (CML). Although experience is too limited to permit evidence-based …

Fungal infections cause more than 1.5 million deaths a year. Due to emerging antifungal
drug resistance, novel strategies are urgently needed to combat life-threatening fungal …

Angiogenesis and metastasis are well recognized as processes fundamental to the
development of malignancy. Both processes involve the coordination of multiple cellular and …

The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed
cell death by phosphorylating substrates that regulate both apoptosis and cellular …

Abnormal and exaggerated deposition of extracellular matrix is the hallmark of many fibrotic
diseases, including systemic sclerosis and pulmonary, liver, and kidney fibrosis. The …

The endoplasmic reticulum (ER) stress response constitutes a cellular process that can be
triggered by a great variety of conditions that cause imbalances in intracellular homeostasis …

BCR/ABL-kinase mutations frequently mediate clinical resistance to the selective tyrosine
kinase inhibitor Imatinib mesylate (IM, Gleevec®). However, mechanisms that promote …

An important mediator of cytokine signaling implicated in regulation of hematopoiesis is the
PI3K/protein kinase B (PKB/c-Akt) signaling module. Constitutive activation of this signaling …

Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular
functions associated with malignant transformation and metastasis. Rho GTPases are …