Standing watch over the proteome, molecular chaperones are an ancient and evolutionarily
conserved class of proteins that guide the normal folding, intracellular disposition and …

Interferon-induced protein with tetratricopeptide repeats (IFIT) genes are prominent
interferon-stimulated genes (ISGs). The human IFIT gene family consists of four genes …

Summary BRAF V600E drives tumors by dysregulating ERK signaling. In these tumors, we
show that high levels of ERK-dependent negative feedback potently suppress ligand …

Recent research has examined Akt and Akt-related serine–threonine kinases in signaling
cascades that regulate cell survival and are important in the pathogenesis of degenerative …

Abstract Heat shock protein 90 (Hsp90) is a molecular chaperone essential for activating
many signaling proteins in the eukaryotic cell. Biochemical and structural analysis of Hsp90 …

Alzheimer's disease (AD) is neurodegenerative disorder that is associated with memory and
cognitive decline in the older adults. Scopolamine is commonly used as a behavioral model …

Hsp90 is a major molecular chaperone that is expressed abundantly and plays a pivotal role
in assisting correct folding and functionality of its client proteins in cells. The Hsp90 client …

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

Cells are faced with the task of folding thousands of different polypeptides into a wide range
of conformations. For many proteins, the folding process requires the action of molecular …

Comparing independent high-throughput gene-expression experiments can generate
hypotheses about which gene-expression programs are shared between particular …