Cancer divergence has many facets other than being considered a genetic term. It is a
tremendous challenge to understand the metastasis and therapy response in cancer …

The mucosal surfaces that form the boundary between the external environment and the
underlying tissue are protected by a mucus barrier. Mucin glycoproteins, both secreted and …

Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis
and is a major challenge to current treatments. Cancer cells commonly evade apoptosis …

Cancer‐associated fibroblasts (CAFs) promote cancer stem cell (CSC)‐mediated
chemoresistance and immunosuppressive tumor microenvironment. However, direct …

Cell surface mucin (cs-mucin) glycoproteins are constitutively expressed at the surface of
respiratory epithelia where pathogens such as influenza A virus (IAV) gain entry into cells …

Background & Aims Mucin 13 (MUC13) is reportedly overexpressed in human malignancies.
However, the clinicopathological and biological significance of MUC13 in human …

Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths in the world.
Drug resistance of tumour cells remains the main challenge toward curative treatments …

DNA damage is a vital challenge to cell homeostasis. Cellular responses to DNA damage
(DDR) play essential roles in maintaining genomic stability and survival, whose failure could …

Cancer stem cells (CSCs), which have a close connection with tumor microenvironment,
play a pivotal role in tumorigenesis, tumor progression, and metastasis. The inflammatory …

The cancer burden continues to grow globally, and drug resistance remains a substantial
challenge in cancer therapy. It is well established that cancerous cells with clonal dysplasia …