Anticancer potential of coumarin and its derivatives

N Bhattarai, AA Kumbhar, YR Pokharel… - Mini Reviews in …, 2021 - ingentaconnect.com
Coumarins are found in higher plants like Rutaceae and Umbelliferae and essential oils of
cinnamon bark, cassia leaf, and lavender oil. Coumarin compounds show different …

[HTML][HTML] Umbelliferone: Sources, chemistry and bioactivities review

O Mazimba - Bulletin of Faculty of Pharmacy, Cairo University, 2017 - Elsevier
Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely
distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently …

Scopoletin: A review of its source, biosynthesis, methods of extraction, and pharmacological activities

LD Antika, AN Tasfiyati, H Hikmat… - … für Naturforschung C, 2022 - degruyter.com
Scopoletin, also known as 6-methoxy-7 hydroxycoumarin, is one of the naturally occurring
coumarin commonly found in many edible plants and plays an important role in human …

Recent advances in biologically active coumarins from marine sources: Synthesis and evaluation

L Fernández-Peña, MJ Matos, E López - Marine Drugs, 2022 - mdpi.com
Coumarin and its derivatives have significantly attracted the attention of medicinal chemists
and chemical biologists due to their huge range of biological, and in particular …

Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells

SM Yu, DH Hu, JJ Zhang - Molecular medicine reports, 2015 - spandidos-publications.com
Hepatocellular carcinoma (HCC) is a highly malignant tumor, associated with poor patient
prognoses, and high rates of morbidity and mortality. To date, the therapeutic strategies …

7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro

M KIEŁBUS, K SKALICKA-WOŹNIAK… - Anticancer …, 2013 - ar.iiarjournals.org
Background: Coumarins are a large group of naturally-occurring compounds with a wide
range of biological properties, including anticancer activity. 7-Substituted coumarins …

Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin

FO de Lima, FR Nonato, RD Couto… - Journal of natural …, 2011 - ACS Publications
7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported
to produce potent antinociceptive effects in animal models of pain. However, the …

Dietary umbelliferone attenuates alcohol-induced fatty liver via regulation of PPARα and SREBP-1c in rats

MJ Kim, MO Sim, HI Lee, JR Ham, KI Seo, MK Lee - Alcohol, 2014 - Elsevier
This study investigated the effects of umbelliferone (UF) on alcoholic fatty liver and its
underlying mechanism. Rats were fed a Lieber–DeCarli liquid diet with 36% of calories as …

Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies

S Verma, P Khambhala, S Joshi… - Experimental …, 2019 - exp-oncology.com.ua
Asafoetida resin has been reported for various biological activities but its use has been
widely restricted owing to its pungent smell and pool water solubility. Aim: In vitro study of …

Synthesis, characterization and cytotoxic/cytostatic activity of La (III) and Dy (III) complexes

I Kostova, T Stefanova - Journal of Trace Elements in Medicine and Biology, 2010 - Elsevier
New La (III) and Dy (III) complexes of deprotonated 4-hydroxy-3 [1-(4-nitrophenyl)-3-
oxobutyl]-2H-1-benzopyran-2-one (Acenocoumarol) were synthesized and characterized …