Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …

G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and
pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and …

G protein–coupled receptors (GPCRs) are the largest gene family of cell membrane–
associated molecules mediating signal transmission, and their involvement in key …

The desmoplastic reaction of pancreas cancer may begin as a wound healing response to
the nascent neoplasm, but it soon creates an insidious shelter that can sustain the growing …

Despite progress, 2-year pancreatic cancer survival remains dismal. We evaluated a
biomarker-driven, combination/N-of-one strategy in 18 patients (advanced/metastatic …

Background Treatment outcomes for patients with advanced pancreatic ductal
adenocarcinoma (PDAC) remain dismal. There are unmet needs for understanding the …

Simple Summary Pancreatic cancer is a highly malignant disease with treatment resistance
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …

Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are bona fide precursor
lesions of pancreatic ductal adenocarcinoma (PDAC). The most common subtype of IPMNs …

Pancreatic intraductal papillary mucinous neoplasms (IPMNs) have gained substantial
attention because they represent one of the only radiographically identifiable precursors of …