Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Host immunity recognizes and eliminates most early tumor cells, yet immunological
checkpoints, exemplified by CTLA-4, PD-1, and PD-L1, pose a significant obstacle to …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Triple negative breast cancer (TNBC) is a complex and aggressive subtype of breast cancer
which lacks oestrogen receptors, progesterone receptors and HER2 amplification, thereby …

Background Biocompatibility and stability of zinc oxide nanoparticles (ZnO NPs) synthesized
using plants is an interesting research area of study in nanotechnology, due to its wide …

Membrane potential (Vm), the voltage across the plasma membrane, arises because of the
presence of different ion channels/transporters with specific ion selectivity and permeability …

The voltage-gated sodium channel NaV1. 7 is preferentially expressed in peripheral somatic
and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons …

It is well known that electrical signals are deeply associated with living entities. Much of our
understanding of excitable tissues is derived from studies of specialized cells of neurons or …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

PURPOSE Preventing metastases by using perioperative interventions has not been
adequately explored. Local anesthesia blocks voltage-gated sodium channels and thereby …