Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

Extracellular vesicles (EVs) are a potential source of disease-associated biomarkers for
diagnosis. In breast cancer, comprehensive analyses of EVs could yield robust and reliable …

Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with a complex
microenvironment. Dichotomous tumour-promoting and-restrictive roles have been ascribed …

Despite available targeted treatments for the disease, drug-resistant chronic lymphocytic
leukemia (CLL) poses a clinical challenge. The objective of this study is to examine whether …

Inflammatory bowel diseases present with elevated levels of intestinal epithelial cell (IEC)
death, which compromises the gut barrier, activating immune cells and triggering more IEC …

The glucocorticoid receptor (GR) regulates gene expression, governing aspects of
homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently …

Combination of CDK4/6 inhibitors and endocrine therapy improves clinical outcome in
advanced oestrogen receptor (ER)-positive breast cancer, however relapse is inevitable …

Cytomegaloviruses (CMVs) have co-evolved with their mammalian hosts for millions of
years, leading to remarkable host specificity and high infection prevalence. Macrophages …

Background Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with
minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth and is …