The past decade of cell cycle investigations has identified many roads not taken. The kinase
that drives mitosis can be modulated by cyclins, by activating phosphorylation, by inhibitory …

Cell-division control affects many aspects of development. Caenorhabditis elegans cell-
cycle genes have been identified over the past decade, including at least two distinct Cyclin …

We used DNA microarrays to profile gene expression patterns in the C. elegans germline
and identified 1416 germline-enriched transcripts that define three groups. The sperm …

Two B-type cyclins, B1 and B2, have been identified in mammals. Proliferating cells express
both cyclins, which bind to and activate p34cdc2. To test whether the two B-type cyclins have …

In eukaryotes, mitosis is initiated by M phase promoting factor (MPF), composed of B-type
cyclins and their partner protein kinase, CDK1. In animal cells, MPF is cytoplasmic in …

The eukaryotic ubiquitin-conjugation system sets the turnover rate of many proteins and
includes activating enzymes (E1s), conjugating enzymes (UBCs/E2s), and ubiquitin-protein …

While entry into mitosis is triggered by activation of cdc2 kinase, exit from mitosis requires
inactivation of this kinase. Inactivation results from proteolytic degradation of the regulatory …

In the eukaryotic cell cycle, a threshold level of cyclin B accumulation triggers the G2-to-M
transition, and subsequent cyclin B destruction triggers mitotic exit. The anaphase-promoting …

Cyclin B3 has been conserved during higher eukaryote evolution as evidenced by its
identification in chicken, nematodes, and insects. We demonstrate that Cyclin B3 is present …

Results The control of cyclin E transcription in endoreduplicating and mitotically proliferating
tissues is distinct To determine whether cyclin E can regulate its own expression, we …