Bioactivity of natural polyphenols as antiparasitic agents and their biochemical targets

J Soto-Sánchez - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Background: Leishmaniasis and trypanosomiasis are diseases that affect public health
worldwide due to their high incidence, morbidity, and mortality. Available treatments are …

Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer's Disease

FJ Mirza, S Zahid, S Amber, H Jabeen, N Asim… - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) has been associated with the hallmark features of cholinergic
dysfunction, amyloid beta (Aβ) aggregation and impaired synaptic transmission, which …

Evaluation of Antimalarial Activity of Ethanolic Extract of Annona muricata L.: An in vivo and an in silico Approach

CO Nwonuma, EA Balogun… - Journal of Evidence …, 2023 - journals.sagepub.com
In Nigeria, Annona muricata L. has been used to treat a variety of ailments. The mechanism
of the antimalarial activity of ethanolic leaf extract of Annona muricata (EEAML) was …

A systematic review on ethnobotany, phytochemistry and pharmacology of Dioscorea bulbifera L.(Dioscoreaceae)

S Sharma, S Kaul, MK Dhar - South African Journal of Botany, 2024 - Elsevier
Dioscorea bulbifera L.(Dioscoreaceae) is extensively being used in African, Chinese and
Indian traditional medicinal systems since ages. It is an ingredient in many herbal and …

An Allosteric Inhibitory Potential of Triterpenes from Combretum racemosum on the Structural and Functional Dynamics of Plasmodium falciparum Lactate …

WM Oluyemi, BB Samuel, AT Adewumi… - Chemistry & …, 2022 - Wiley Online Library
Multidrug resistance is a significant drawback in malaria treatment, and mutations in the
active sites of the many critical antimalarial drug targets have remained challenging …

Antimalarial potential of compounds isolated from Mammea siamensis T. Anders. flowers: in vitro and molecular docking studies

P Chaniad, A Chukaew, A Payaka… - … medicine and therapies, 2022 - Springer
Background: The emergence of antimalarial drug resistance encourages the search for new
antimalarial agents. Mammea siamensis belongs to the Calophyllaceae family, which is a …

In Silico Studies of Four Compounds of Cecropia obtusifolia against Malaria Parasite

CA Lobato-Tapia, Y Moreno-Hernández… - Molecules, 2023 - mdpi.com
Malaria is a disease that affects many people in the world. In Mexico, malaria remains an
active disease in certain regions, particularly in the states of Chiapas and Chihuahua. While …

Antiplasmodial potential of isolated xanthones from Mesua ferrea Linn. roots: an in vitro and in silico molecular docking and pharmacokinetics study

A Konyanee, P Chaniad, A Chukaew, A Payaka… - … Medicine and Therapies, 2024 - Springer
Background Malaria is a major global health concern, particularly in tropical and subtropical
countries. With growing resistance to first-line treatment with artemisinin, there is an urgent …

30-norfriedelanes and other compounds from the stem bark and fruits of Caloncoba glauca (Achariaceae), their antiplasmodial activity, structure-activity relationship …

KG Sikam, GM Happi, SA Ahmed, LC Dzouemo… - Fitoterapia, 2023 - Elsevier
Two new 30-norfriedelane triterpenoids namely glaucalactone C (1) and glaucanoic acid (2)
along with sixteen known compounds (3–18) have been isolated from the methanolic …

Structure-based virtual screening against multiple Plasmodium falciparum kinases reveals antimalarial compounds

P Godara, KS Reddy, W Sahu, B Naik, V Srivastava… - Molecular Diversity, 2023 - Springer
The continuous emergence of resistance against most frontline antimalarial drugs has led to
countless deaths in malaria-endemic countries, counting 619,000 deaths in 2021, with …