The rapid development of effective vaccines to combat the SARS-CoV-2 virus has been an
effective counter measure to decrease hospitalization and the mortality rate in many …

Cathepsin C (CatC) is a cysteine dipeptidyl aminopeptidase that activates most of tissue-
degrading elastase-related serine proteases. Thus, CatC appears as a potential therapeutic …

Cathepsin C, an important lysosomal cysteine protease, mediates the maturation process of
neutrophil serine proteases, and participates in the inflammation and immune regulation …

Rheumatoid arthritis (RA) is a painful and incurable disease characterized by chronic joint
inflammation and a progressive destruction of cartilage and bone. Although current …

Epidemiological studies established an association between chronic inflammation and
higher risk of cancer. Inhibition of proteolytic enzymes represents a potential treatment …

Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the
endolysosomal compartment where they mediate protein degradation and turnover …

The loss of smell (anosmia) related to SARS-CoV-2 infection is one of the most common
symptoms of COVID-19. Olfaction starts in the olfactory epithelium mainly composed of …

During inflammation neutrophils become activated and segregate neutrophil serine
proteases (NSPs) to the surrounding environment in order to support a natural immune …

Background The ANCA autoantigens proteinase 3 (PR3) and myeloperoxidase (MPO) are
exclusively expressed by neutrophils and monocytes. ANCA-mediated activation of these …

Endothelial cell dysfunction is an essential pathophysiological feature of preeclampsia (PE).
It has been reported that cathepsin C is upregulated in the maternal vascular endothelium of …