Therapeutic efficacy of nanoparticles and routes of administration

D Chenthamara, S Subramaniam… - Biomaterials …, 2019 - spj.science.org
In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable
tools in disease monitoring and therapy. The term “nanomaterials” describes materials with …

Towards more accurate bioimaging of drug nanocarriers: turning aggregation-caused quenching into a useful tool

J Qi, X Hu, X Dong, Y Lu, H Lu, W Zhao… - Advanced Drug Delivery …, 2019 - Elsevier
One of the current challenges in the monitoring of drug nanocarriers lies in the difficulties in
discriminating the carrier-bound signals from the bulk signals of probes. Environment …

Relationship between particle size and lung retention time of intact solid lipid nanoparticle suspensions after pulmonary delivery

Z Huang, Y Huang, W Wang, F Fu, W Wang… - Journal of Controlled …, 2020 - Elsevier
The relationship between the particle size and lung retention time of inhaled nanocarriers
was unclear, and this uncertainty hampered the design of nanocarriers for pulmonary …

Enhancing targeted cancer treatment by combining hyperthermia and radiotherapy using Mn–Zn ferrite magnetic nanoparticles

Y Wang, L Zou, Z Qiang, J Jiang, Z Zhu… - … Biomaterials Science & …, 2020 - ACS Publications
Radiotherapy (RT) is a major treatment method for non-small-cell lung cancer (NSCLC), and
development of new treatment modality is now critical to amplify the negative effects of RT …

Nanoparticle delivery platforms for RNAi therapeutics targeting COVID-19 disease in the respiratory tract

Y Zhang, JG Almazi, HX Ong, MD Johansen… - International journal of …, 2022 - mdpi.com
Since December 2019, a pandemic of COVID-19 disease, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has rapidly spread across the globe. At …

Poly(lactide-co-glycolide) Nanoparticles Mediate Sustained Gene Silencing and Improved Biocompatibility of siRNA Delivery Systems in Mouse Lungs after …

L Wu, LP Wu, J Wu, J Sun, Z He… - … Applied Materials & …, 2021 - ACS Publications
Pulmonary delivery of small interfering RNA (siRNA)-based drugs is promising in treating
severe lung disorders characterized by the upregulated expression of disease-causing …

Major difference in particle size, minor difference in release profile: A case study of solid lipid nanoparticles

Z Huang, L Wu, W Wang, W Wang, F Fu… - Pharmaceutical …, 2021 - Taylor & Francis
Solid lipid nanoparticles (SLN) have been widely used in a variety of drug delivery routes,
which have the outstanding advantage of controlled drug release. The release of SLN is …

How can aggregation-caused quenching based bioimaging of drug nanocarriers be improved?

H Yuan, W Zhao, W Wu - Therapeutic Delivery, 2020 - Taylor & Francis
Drug-delivery systems (DDS) based on nanocarriers have been the focus of research for
more than 30 years, evidenced by the enormous input of investment and human resources …

[HTML][HTML] 纳米药物载体体内命运研究: 环境响应型荧光染料的应用

戚建平, 卢懿, 董肖椿, 赵伟利, 吴伟 - 药学学报, 2019 - html.rhhz.net
纳米制剂的体内命运研究关乎其临床转化的成败, 目前所面临的最大挑战之一是如何在体内实时
准确地监测纳米载体自身. 传统的放射或荧光探针从被标记母体粒子解离后, 依然发射信号 …