The signals and mechanisms that synchronize the timing of human parturition remain a
mystery and a better understanding of these processes is essential to avert adverse …

Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

Abstract Background Cadmium (Cd), lead (Pb), and mercury (Hg) have been shown to
exhibit endocrine disrupting properties. Their effects on women's reproductive health …

Identification of pregnancies at risk of preterm birth (PTB), the leading cause of newborn
deaths, remains challenging given the syndromic nature of the disease. We report a …

Preterm birth affects approximately 1 out of every 10 births in the United States, leading to
high rates of mortality and long-term negative health consequences. To investigate the …

Progesterone is required for the establishment and maintenance of mammalian pregnancy
and widely used for conservative treatment of luteal phase deficiency in clinics. However …

The steroid hormones progesterone (P4) and estradiol-17β (E2), produced by the placenta
in humans and the ovaries in rodents, serve crucial roles in the maintenance of pregnancy …

Parturition at term in normal pregnancy follows a predictable sequence of events. There is
some evidence that a state of inflammation prevails in the reproductive tissues during labor …

Myometrium holds the structural integrity for the uterus and generates force for parturition
with its primary component, the smooth muscle cells. The progesterone receptor mediates …

Many studies have shown roles for endoplasmic reticulum stress (ERS)/unfolded protein
response (UPR) signaling cascades with ovarian folliculogenesis, and oocyte maturation. In …