Production of chitooligosaccharides and their potential applications in medicine

BB Aam, EB Heggset, AL Norberg, M Sørlie, KM Vårum… - Marine drugs, 2010 - mdpi.com
Chitooligosaccharides (CHOS) are homo-or heterooligomers of N-acetylglucosamine and D-
glucosamine. CHOS can be produced using chitin or chitosan as a starting material, using …

Chitinases and immunity: ancestral molecules with new functions

M Di Rosa, G Distefano, K Zorena, L Malaguarnera - Immunobiology, 2016 - Elsevier
Chitinases belonging to 18 glycosyl hydrolase family is an ancient gene family that is widely
expressed from prokaryotes to eukaryotes. In humans, despite the absence of endogenous …

The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases

C Ober, GL Chupp - Current opinion in allergy and clinical …, 2009 - journals.lww.com
These genes represent novel asthma susceptibility genes. Variations in CHI3L1 and CHIA
have been associated with asthma risk. Polymorphisms in CHIT1 have not yet been …

Evaluation of CHI3L-1 and CHIT-1 expression in differentiated and polarized macrophages

M Di Rosa, G Malaguarnera, C De Gregorio, F Drago… - Inflammation, 2013 - Springer
Abstract Chitinase 3-like protein 1 (CHI3L-1) and chitotriosidase (CHIT-1) are members of
the chitinase family. CHI3L-1 is a newly recognized protein that is secreted by activated …

Human chitotriosidase-catalyzed hydrolysis of chitosan

KB Eide, AL Norberg, EB Heggset, AR Lindbom… - Biochemistry, 2012 - ACS Publications
Chitotriosidase (HCHT) is one of two family 18 chitinases produced by humans, the other
being acidic mammalian chitinase (AMCase). The enzyme is thought to be part of the human …

Modulation of chitotriosidase during macrophage differentiation

M Di Rosa, G Malaguarnera, C De Gregorio… - Cell biochemistry and …, 2013 - Springer
Macrophages as a principal component of immune system play an important role in the
initiation, modulation, and final activation of the immune response against pathogens. Upon …

Chitotriosidase: a new inflammatory marker in diabetic complications

M Di Rosa, L Malaguarnera - Pathobiology, 2016 - karger.com
Chitotriosidase (CHIT1) belongs to chitinase family. So far this enzyme has been the best
investigated human chitinase regarding its biological activity and association with various …

Using nationwide'big data'from linked electronic health records to help improve outcomes in cardiovascular diseases: 33 studies using methods from epidemiology …

H Hemingway, GS Feder, NK Fitzpatrick… - … grants for applied …, 2017 - discovery.ucl.ac.uk
BACKGROUND: Electronic health records (EHRs), when linked across primary and
secondary care and curated for research use, have the potential to improve our …

Modeling immune system control of atherogenesis

F Pappalardo, S Musumeci, S Motta - Bioinformatics, 2008 - academic.oup.com
Motivation: Atherosclerosis is a disease that is present in almost all humans, typically
beginning in early adolescence. It is a human disease broadly investigated, that is …

The chitinases expression is related to Simian Immunodeficiency Virus Encephalitis (SIVE) and in HIV encephalitis (HIVE)

C Sanfilippo, G Nunnari, A Calcagno, L Malaguarnera… - Virus research, 2017 - Elsevier
Abstract Objectives Human Immunodeficiency Virus (HIV) infection can induce
neurocognitive complications classified as HIV-associated neurocognitive disorder (HAND) …