The clinical use of anthracyclines like doxorubicin and daunorubicin can be viewed as a sort
of double-edged sword. On the one hand, anthracyclines play an undisputed key role in the …

Neoadjuvant chemotherapy (NAC) for breast cancer is evolving and subsequent adjuvant
systemic treatment is mainly based on the presence of the Estrogen (ER) receptor …

Purpose To compare the prognostic significance of proliferation, as assessed by Ki67
expression, in breast cancer before and after neoadjuvant chemotherapy. Methods A …

Invasive breast cancer is a heterogeneous disease in its presentation, pathological
classification and clinical course. However, there are more than a dozen variants which are …

Doxorubicin-induced cardiotoxicity in childhood cancer survivors is a growing problem. The
population of patients at risk for cardiovascular disease is steadily increasing, as five-year …

A prospective study was undertaken in women undergoing neoadjuvant chemotherapy for
locally advanced breast cancer in order to determine the ability of quantitative magnetic …

Oestrogen receptor (ER) negative breast cancers are more likely to achieve a pathological
complete response (pCR) to neoadjuvant chemotherapy compared to those with ER positive …

Obesity is associated with an increased risk of breast cancer. Leptin, a hormone synthesised
essentially by adipose tissue, may be involved in cancer development. We examined the …

Neoadjuvant chemotherapy (NAC) is now a relatively standard treatment for breast
carcinoma. However, some tumors are known to develop resistance to chemotherapies. We …

Anthracycline antibiotic doxorubicin (DOX) belongs among the most important
antineoplastics used in cancer therapy. Unfortunately, its cytostatic effect in therapeutic …