Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes

LDJ Bos, LB Ware - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

EA Gorman, CM O'Kane, DF McAuley - The Lancet, 2022 - thelancet.com
Acute respiratory distress syndrome (ARDS) is characterised by acute hypoxaemic
respiratory failure with bilateral infiltrates on chest imaging, which is not fully explained by …

Simvastatin in critically ill patients with Covid-19

REMAP-CAP Investigators - New England Journal of Medicine, 2023 - Mass Medical Soc
Background The efficacy of simvastatin in critically ill patients with coronavirus disease 2019
(Covid-19) is unclear. Methods In an ongoing international, multifactorial, adaptive platform …

In-hospital use of statins is associated with a reduced risk of mortality among individuals with COVID-19

XJ Zhang, JJ Qin, X Cheng, L Shen, YC Zhao, Y Yuan… - Cell metabolism, 2020 - cell.com
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have
been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk …

Practitioner's guide to latent class analysis: methodological considerations and common pitfalls

P Sinha, CS Calfee, KL Delucchi - Critical care medicine, 2021 - journals.lww.com
Latent class analysis is a probabilistic modeling algorithm that allows clustering of data and
statistical inference. There has been a recent upsurge in the application of latent class …

Personalized mechanical ventilation in acute respiratory distress syndrome

P Pelosi, L Ball, CSV Barbas, R Bellomo, KEA Burns… - Critical care, 2021 - Springer
A personalized mechanical ventilation approach for patients with adult respiratory distress
syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging …

COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies

D Atri, HK Siddiqi, JP Lang, V Nauffal… - Basic to Translational …, 2020 - jacc.org
Summary Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe
acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As …

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

P Sinha, CS Calfee, S Cherian, D Brealey… - The Lancet …, 2020 - thelancet.com
Background In acute respiratory distress syndrome (ARDS) unrelated to COVID-19, two
phenotypes, based on the severity of systemic inflammation (hyperinflammatory and …

Latent class analysis reveals COVID-19–related acute respiratory distress syndrome subgroups with differential responses to corticosteroids

P Sinha, D Furfaro, MJ Cummings… - American journal of …, 2021 - atsjournals.org
Rationale: Two distinct subphenotypes have been identified in acute respiratory distress
syndrome (ARDS), but the presence of subgroups in ARDS associated with coronavirus …

Critical care management of adults with community-acquired severe respiratory viral infection

YM Arabi, R Fowler, FG Hayden - Intensive care medicine, 2020 - Springer
With the expanding use of molecular assays, viral pathogens are increasingly recognized
among critically ill adult patients with community-acquired severe respiratory illness; studies …