Glucocorticoids (GCs) are steroid hormones that are necessary for life and important in
health and disease. They regulate crucial homeostatic functions, including metabolism, cell …

The innate immune system of mammals responds to microbial infection through detection of
conserved molecular determinants called 'pathogen‐associated molecular …

Aggregation of tau protein in the brain is associated with a class of neurodegenerative
diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by …

The innate immune system is the first line of defense against invading pathogens. Innate
immune cells recognize molecular patterns from the pathogen and mount a response to …

Background Glucocorticoids (GCs) are a first-line treatment for asthma for their anti-
inflammatory effects, but they also hinder the repair of airway epithelial injury. The anti …

Dendritic cells (DCs) are key antigen-presenting cells that control the induction of both
tolerance and immunity. Understanding the molecular mechanisms regulating DCs …

Virulence of Yersinia pestis in mammals requires the type III secretion system, which
delivers seven effector proteins into the cytoplasm of host cells to undermine immune …

Various pathogens systematically reprogram gene expression in macrophages, but the
underlying mechanisms are largely unknown. We investigated whether the enteropathogen …

Pathogenic Yersinia spp. extensively suppress expression of inflammatory genes via
injection of virulence plasmid-encoded factors into macrophages. At this point a global …

Various pathogens systematically reprogram gene expression in innate immune cells, but
the underlying mechanisms are largely unknown. We investigated whether the …