The Cancer Antioxidant Regulation System in Therapeutic Resistance
X Gu, C Mu, R Zheng, Z Zhang, Q Zhang, T Liang - Antioxidants, 2024 - mdpi.com
Antioxidants play a pivotal role in neutralizing reactive oxygen species (ROS), which are
known to induce oxidative stress. In the context of cancer development, cancer cells adeptly …
known to induce oxidative stress. In the context of cancer development, cancer cells adeptly …
One-carbon metabolism shapes T cell immunity in cancer
Y Qiu, E Xie, H Xu, H Cheng, G Li - Trends in Endocrinology & Metabolism, 2024 - cell.com
Abstract One-carbon metabolism (1CM), comprising folate metabolism and methionine
metabolism, serves as an important mechanism for cellular energy provision and the …
metabolism, serves as an important mechanism for cellular energy provision and the …
Exploring the Anticancer Potential of Furanpydone A: A Computational Study on its Inhibition of MTHFD2 Across Diverse Cancer Cell Lines
MB Alhawarri - Cell Biochemistry and Biophysics, 2024 - Springer
Cancer poses a significant global health challenge due to its high mortality rate and complex
treatment strategies. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), which is …
treatment strategies. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), which is …
Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and …
HH Chang, LC Lee, T Hsu, YH Peng… - Journal of Medicinal …, 2024 - ACS Publications
Methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2), a pivotal
mitochondrial enzyme in one-carbon metabolism, is significantly upregulated in various …
mitochondrial enzyme in one-carbon metabolism, is significantly upregulated in various …
Construction of breast cancer-related gene prognostic signature in endometrial cancer
J Xu, H Zhang, X Qin, K Zhang, T He, X Ma, Y Su… - 2024 - researchsquare.com
Objective Breast cancer (BC) and endometrial cancer (EC) both originate from sex hormone-
dependent organs, yet their interaction mechanisms remain unclear. This study aims to …
dependent organs, yet their interaction mechanisms remain unclear. This study aims to …