Epigenetic dysregulation is a common feature of most cancers, often occurring directly
through alteration of epigenetic machinery. Over the last several years, a new generation of …

Chromatin regulatory proteins are increasingly recognized as potential new drug targets.
Many of these proteins harbor one or more so called 'reader domains' that recognize …

SMNDC1 is a Tudor domain protein that recognizes di-methylated arginines and controls
gene expression as an essential splicing factor. Here, we study the specific contributions of …

Abnormal lipid metabolism plays crucial roles in the development of cancer. Spindlin 1
(SPIN1) involving the process of spindle organization and chromosomal stability serves as …

Histone post-translational modifications (PTMs) and their recognition by histone readers
exert crucial functions in eukaryotes. Despite extensive studies, conservation and diversity of …

Histone methylation reader domains are protein modules that recognize specific histone
methylation marks, such as methylated or unmethylated lysine or arginine residues on …

Chemical modifications on histones and DNA/RNA constitute a fundamental mechanism for
epigenetic regulation. These modifications often function as docking marks to recruit or …

Methylation of arginine (Arg) residues on histones creates a new binding epitope, enabling
recognition by aromatic cage binding pockets in Tudor domains; these protein–protein …

In the last 40 years, cation− π interactions have become part of the lexicon of noncovalent
forces that drive protein binding. Indeed, tetraalkylammoniums are universally bound by …

SET domain bifurcated protein 1 (SETDB1) is a histone lysine methyltransferase that
promotes the silencing of some tumour suppressor genes and is overexpressed in many …