Dietary polyphenols have been the focus of major interest for their potential benefits on
human health. Several preclinical studies have been conducted to provide a rationale for …

Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), currently affect more …

Metformin is used for the treatment of insulin resistant diabetes. Diabetics are at an
increased risk of developing dementia. Recent epidemiological studies suggest that …

Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or
delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria …

Alzheimer's disease (AD) is a highly age-related cognitive decline frequently attacking the
elderly. Senescence-accelerated mouse-prone 8 (SAMP8) is an ideal model to study AD …

Aging is a major driving force underlying dementia, such as that caused by Alzheimer's
disease (AD). While the idea of targeting aging as a therapeutic strategy is not new, it …

With innumerable clinical failures of target-specific drug candidates for multifactorial
diseases, such as Alzheimer's disease (AD), which remains inefficiently treated, the advent …

Almost a half century ago, the free radical theory of ageing proposed that the reactive
oxygen species (ROS) is a key component which contributes to the pathophysiology of …