Allelopathy is the biological phenomenon of chemical interactions between living organisms
in the ecosystem, and must be taken into account in addressing pest and weed problems in …

Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

Transaminases have attracted considerable interest in their use as biocatalysts for the
synthesis of compounds containing chiral amine units, which are widespread within the …

Covering: up to mid-2018 Pyridoxal 5′-phosphate (PLP) is a versatile organic cofactor
used to catalyze diverse reactions on amino acid, oxoacid, and amine substrates. Here we …

Carboxylic acid reductase (CAR) catalyzes the ATP-and NADPH-dependent reduction of
carboxylic acids to the corresponding aldehydes. The enzyme is related to the nonribosomal …

Covering: up to 2018 Thioester reductase domains catalyze two-and four-electron
reductions to release natural products following assembly on nonribosomal peptide …

Covering: up to 2023 The marine environment represents a rich yet challenging source of
novel therapeutics. These challenges are best exemplified by the manzamine class of …

The formicamycin biosynthetic gene cluster encodes two groups of type 2 polyketide
antibiotics: the formicamycins and their biosynthetic precursors the fasamycins, both of …

The Milstein's reported discovery of hydrogenation of thioesters directly toward thiols and
alcohols catalyzed by a Ru-acridine complex has been studied here by DFT calculations to …

Polyketide synthases assemble diverse natural products with numerous important
applications. The thioester intermediates in polyketide assembly are covalently tethered to …