Immunoregulatory roles of eosinophils: a new look at a familiar cell
P Akuthota, HB Wang, LA Spencer… - Clinical & Experimental …, 2008 - Wiley Online Library
Eosinophils are usually considered as end‐stage degranulating effector cells of innate
immunity. However, accumulating evidence has revealed additional roles for eosinophils …
immunity. However, accumulating evidence has revealed additional roles for eosinophils …
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
DC Fingar, CJ Richardson, AR Tee… - … and cellular biology, 2004 - Am Soc Microbiol
The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to
regulate cell growth (increased cell mass and cell size) and cell division. The …
regulate cell growth (increased cell mass and cell size) and cell division. The …
Role of transcription factors in the pathogenesis of asthma and COPD
G Caramori, P Casolari, I Adcock - Cell communication & adhesion, 2013 - Taylor & Francis
Inflammation is a central feature of asthma and chronic obstructive pulmonary disease
(COPD). Despite recent advances in the knowledge of the pathogenesis of asthma and …
(COPD). Despite recent advances in the knowledge of the pathogenesis of asthma and …
The STAT5–GATA2 pathway is critical in basophil and mast cell differentiation and maintenance
Transcription factor GATA binding protein 2 (GATA2) plays critical roles in hematopoietic
stem cell survival and proliferation, granulocyte–monocyte progenitor differentiation, and …
stem cell survival and proliferation, granulocyte–monocyte progenitor differentiation, and …
Interferon‐λ1 (interleukin‐29) preferentially down‐regulates interleukin‐13 over other T helper type 2 cytokine responses in vitro
S Srinivas, J Dai, J Eskdale, GE Gallagher… - …, 2008 - Wiley Online Library
Summary Interferon (IFN)‐λ1 [interleukin (IL)‐29] is a member of the interferon lambda family
(also known as type III interferons), whose members are distantly related to both the type I …
(also known as type III interferons), whose members are distantly related to both the type I …
[HTML][HTML] TNF-α enhances Th9 cell differentiation and antitumor immunity via TNFR2-dependent pathways
Y Jiang, J Chen, E Bi, Y Zhao, T Qin, Y Wang… - … for immunotherapy of …, 2019 - Springer
Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers.
TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of …
TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of …
The membrane-associated ubiquitin ligases MARCH2 and MARCH3 target IL-5 receptor alpha to negatively regulate eosinophilic airway inflammation
LW Zeng, L Feng, R Liu, H Lin, HB Shu… - Cellular & molecular …, 2022 - nature.com
Abstract Interleukin 5 (IL-5) plays crucial roles in type 2-high asthma by mediating eosinophil
maturation, activation, chemotaxis and survival. Inhibition of IL-5 signaling is considered a …
maturation, activation, chemotaxis and survival. Inhibition of IL-5 signaling is considered a …
[HTML][HTML] IL-33-induced cytokine secretion and survival of mouse eosinophils is promoted by autocrine GM-CSF
R Willebrand, D Voehringer - PloS one, 2016 - journals.plos.org
Eosinophils are major effector cells during allergic responses and helminth infections.
Recent studies further highlight eosinophils as important players in many other biological …
Recent studies further highlight eosinophils as important players in many other biological …
[HTML][HTML] Inflammation and infections in asthma
A Gillissen, M Paparoupa - The clinical respiratory journal, 2014 - pmc.ncbi.nlm.nih.gov
Introduction Asthma is driven by an inflammatory response against normally harmless
environmental inorganic and organic compounds in the respiratory tract. Immune responses …
environmental inorganic and organic compounds in the respiratory tract. Immune responses …
[HTML][HTML] Marked induction of c-Maf protein during Th17 cell differentiation and its implication in memory Th cell development
K Sato, F Miyoshi, K Yokota, Y Araki, Y Asanuma… - Journal of Biological …, 2011 - ASBMB
Until recently, effector T helper (Th) cells have been classified into two subsets, Th1 and Th2
cells. Since the discovery of Th17 cells, which produce IL-17, much attention has been given …
cells. Since the discovery of Th17 cells, which produce IL-17, much attention has been given …