[HTML][HTML] Shaping the brain: The emergence of cortical structure and folding

SK Akula, D Exposito-Alonso, CA Walsh - Developmental cell, 2023 - cell.com
The cerebral cortex—the brain's covering and largest region—has increased in size and
complexity in humans and supports higher cognitive functions such as language and …

An evolutionary perspective on complex neuropsychiatric disease

JM McClellan, AW Zoghbi, JD Buxbaum, C Cappi… - Neuron, 2024 - cell.com
The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …

[HTML][HTML] HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex

V Szegedi, E Bakos, S Furdan, BH Kovács… - PLoS …, 2023 - journals.plos.org
Accumulating evidence indicates that there are substantial species differences in the
properties of mammalian neurons, yet theories on circuit activity and information processing …

[HTML][HTML] Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy

E Cho, J Kwon, G Lee, J Shin, H Lee, SH Lee… - Nature …, 2024 - nature.com
Focal cortical dysplasia type I (FCD I) is the most common cause of pharmaco-resistant
epilepsy with the poorest prognosis. To understand the epileptogenic mechanisms of FCD I …

[HTML][HTML] Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types

SLW Driessens, AA Galakhova, DB Heyer… - Nature …, 2023 - nature.com
GWAS have identified numerous genes associated with human cognition but their cell type
expression profiles in the human brain are unknown. These genes overlap with human …

[HTML][HTML] Attention Deficit-Hyperactivity Disorder (ADHD): From Abnormal Behavior to Impairment in Synaptic Plasticity

G Ugarte, R Piña, D Contreras, F Godoy, D Rubio… - Biology, 2023 - mdpi.com
Simple Summary Attention deficit-hyperactivity disorder (ADHD) is a neurodevelopmental
disorder with high incidence in children and adolescents characterized by hyperactivity …

Obesity causally influencing brain cortical structure: a Mendelian randomization study

W Chen, J Feng, J Guo, S Dong, R Li, JCK Ngo… - Cerebral …, 2023 - academic.oup.com
Obesity may lead to cognitive impairment and psychiatric disorders, which are associated
with alterations in the brain cortical structure. However, the exact causality remains …

Cortical origin of theta error signals

B Herrera, A Sajad, SP Errington, JD Schall… - Cerebral …, 2023 - academic.oup.com
A multi-scale approach elucidated the origin of the error-related-negativity (ERN), with its
associated theta-rhythm, and the post-error-positivity (Pe) in macaque supplementary eye …

[HTML][HTML] Distinctive biophysical features of human cell-types: insights from studies of neurosurgically resected brain tissue

HM Chameh, M Falby, M Movahed, K Arbabi… - Frontiers in Synaptic …, 2023 - frontiersin.org
Electrophysiological characterization of live human tissue from epilepsy patients has been
performed for many decades. Although initially these studies sought to understand the …

Volume electron microscopy analysis of synapses in primary regions of the human cerebral cortex

N Cano-Astorga, S Plaza-Alonso, J DeFelipe… - Cerebral …, 2024 - academic.oup.com
Functional and structural studies investigating macroscopic connectivity in the human
cerebral cortex suggest that high-order associative regions exhibit greater connectivity …