[HTML][HTML] Shaping the brain: The emergence of cortical structure and folding
The cerebral cortex—the brain's covering and largest region—has increased in size and
complexity in humans and supports higher cognitive functions such as language and …
complexity in humans and supports higher cognitive functions such as language and …
An evolutionary perspective on complex neuropsychiatric disease
The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …
architecture of human traits, including the genetic architecture of complex neuropsychiatric …
[HTML][HTML] HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex
V Szegedi, E Bakos, S Furdan, BH Kovács… - PLoS …, 2023 - journals.plos.org
Accumulating evidence indicates that there are substantial species differences in the
properties of mammalian neurons, yet theories on circuit activity and information processing …
properties of mammalian neurons, yet theories on circuit activity and information processing …
[HTML][HTML] Net synaptic drive of fast-spiking interneurons is inverted towards inhibition in human FCD I epilepsy
Focal cortical dysplasia type I (FCD I) is the most common cause of pharmaco-resistant
epilepsy with the poorest prognosis. To understand the epileptogenic mechanisms of FCD I …
epilepsy with the poorest prognosis. To understand the epileptogenic mechanisms of FCD I …
[HTML][HTML] Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types
SLW Driessens, AA Galakhova, DB Heyer… - Nature …, 2023 - nature.com
GWAS have identified numerous genes associated with human cognition but their cell type
expression profiles in the human brain are unknown. These genes overlap with human …
expression profiles in the human brain are unknown. These genes overlap with human …
[HTML][HTML] Attention Deficit-Hyperactivity Disorder (ADHD): From Abnormal Behavior to Impairment in Synaptic Plasticity
G Ugarte, R Piña, D Contreras, F Godoy, D Rubio… - Biology, 2023 - mdpi.com
Simple Summary Attention deficit-hyperactivity disorder (ADHD) is a neurodevelopmental
disorder with high incidence in children and adolescents characterized by hyperactivity …
disorder with high incidence in children and adolescents characterized by hyperactivity …
Obesity causally influencing brain cortical structure: a Mendelian randomization study
Obesity may lead to cognitive impairment and psychiatric disorders, which are associated
with alterations in the brain cortical structure. However, the exact causality remains …
with alterations in the brain cortical structure. However, the exact causality remains …
Cortical origin of theta error signals
A multi-scale approach elucidated the origin of the error-related-negativity (ERN), with its
associated theta-rhythm, and the post-error-positivity (Pe) in macaque supplementary eye …
associated theta-rhythm, and the post-error-positivity (Pe) in macaque supplementary eye …
[HTML][HTML] Distinctive biophysical features of human cell-types: insights from studies of neurosurgically resected brain tissue
HM Chameh, M Falby, M Movahed, K Arbabi… - Frontiers in Synaptic …, 2023 - frontiersin.org
Electrophysiological characterization of live human tissue from epilepsy patients has been
performed for many decades. Although initially these studies sought to understand the …
performed for many decades. Although initially these studies sought to understand the …
Volume electron microscopy analysis of synapses in primary regions of the human cerebral cortex
Functional and structural studies investigating macroscopic connectivity in the human
cerebral cortex suggest that high-order associative regions exhibit greater connectivity …
cerebral cortex suggest that high-order associative regions exhibit greater connectivity …