Natural metalloenzymes with astonishing reaction activity and specificity underpin essential
life transformations. Nevertheless, enzymes only operate under mild conditions to keep …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Plastics play an essential role in modern society; however, the relentless growth of their
production is threatening both human health and ecosystems. As a result, there are …

This review is an attempt to retrace the chronicle that starts from the discovery of the role of
nickel as the essential metal ion in urease for the enzymatic catalysis of urea, a key step in …

The impetus to modeling of enzyme active sites comes from their potential to provide insight
to the mechanistic pathways of the native enzymes, establish the role of that particular metal …

Non-covalent interactions in the second coordination sphere of metalloenzymes play a
significant role in determining activity and selectivity. The importance of these interactions is …

Carbapenem-resistant Enterobacteriaceae threaten human health, since carbapenems are
last resort drugs for infections by such organisms. Metallo-β-lactamases (MβLs) are the main …

Coenzyme Q (CoQ) is a redox lipid that fulfills critical functions in cellular bioenergetics and
homeostasis. CoQ is synthesized by a multi-step pathway that involves several COQ …

Two new dimeric Zn (II)([{ZnL 1 (DMSO 2)} 2]· DMSO (1),[{ZnL 2 Cl} 2](2)) and a novel
tetrameric Zn (II) complex ([(Zn 2 L 3) 2 (μ–OAc) 2 (μ 3–O) 2](3)), where H 2 L 1= 4–(p …

The αββα metallo β-lactamase (MBL) fold (MBLf) was first observed in bacterial enzymes
that catalyze the hydrolysis of almost all β-lactam antibiotics, but is now known to be widely …