Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and
monocytes with potent immunosuppressive activity. They are implicated in the regulation of …

Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally
diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain …

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

Gaining a better understanding of the immune cell subsets and molecular factors associated
with protective or pathological immunity against severe acute respiratory syndrome …

Lactate dehydrogenase (LDH) is a terminating enzyme in the metabolic pathway of
anaerobic glycolysis with end product of lactate from glucose. The lactate formation is crucial …

Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19.
Investigating the underlying mechanisms, we find that while primary human airway epithelia …

Disease manifestations in COVID-19 range from mild to severe illness associated with a
dysregulated innate immune response. Alterations in function and regeneration of dendritic …

The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …