History and progress of hypotheses and clinical trials for Alzheimer's disease
PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
Decreased AQP4 expression aggravates ɑ-synuclein pathology in Parkinson's disease mice, possibly via impaired glymphatic clearance
H Cui, W Wang, X Zheng, D Xia, H Liu, C Qin… - Journal of Molecular …, 2021 - Springer
The pathological hallmarks of Parkinson's disease (PD), a neurodegenerative disorder, are
the selective loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and …
the selective loss of dopamine neurons in the substantia nigra pars compacta (SNpc) and …
Optimal mass transport with lagrangian workflow reveals advective and diffusion driven solute transport in the glymphatic system
The glymphatic system (GS) hypothesis states that advective driven cerebrospinal fluid
(CSF) influx from the perivascular spaces into the interstitial fluid space rapidly transport …
(CSF) influx from the perivascular spaces into the interstitial fluid space rapidly transport …
Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models
V Vasciaveo, A Iadarola, A Casile, D Dante… - Acta Neuropathologica …, 2023 - Springer
Alzheimer's disease (AD) is characterized by genetic and multifactorial risk factors. Many
studies correlate AD to sleep disorders. In this study, we performed and validated a mouse …
studies correlate AD to sleep disorders. In this study, we performed and validated a mouse …
Enlarged Perivascular Space and Index for Diffusivity Along the Perivascular Space as Emerging Neuroimaging Biomarkers of Neurological Diseases
J Zhang, S Liu, Y Wu, Z Tang, Y Wu, Y Qi… - Cellular and Molecular …, 2024 - Springer
The existence of lymphatic vessels or similar clearance systems in the central nervous
system (CNS) that transport nutrients and remove cellular waste is a neuroscientific question …
system (CNS) that transport nutrients and remove cellular waste is a neuroscientific question …
Protective effects of aquaporin-4 deficiency on longer-term neurological outcomes in a mouse model
X Liu, Y Xie, X Wan, J Wu, Z Fan, L Yang - Neurochemical Research, 2021 - Springer
Traumatic brain injury (TBI) has been a crucial health problem, with more than 50 million
patients worldwide each year. Glymphatic system is a fluid exchange system that relies on …
patients worldwide each year. Glymphatic system is a fluid exchange system that relies on …
Microglial phagolysosome dysfunction and altered neural communication amplify phenotypic severity in Prader-Willi Syndrome with larger deletion
F Correa-da-Silva, J Carter, XY Wang, R Sun… - Acta …, 2024 - Springer
Abstract Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic
etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of …
etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of …
Super-resolution imaging to reveal the nanostructure of tripartite synapses
N Aleksejenko, JP Heller - Neuronal Signaling, 2021 - portlandpress.com
Even though neurons are the main drivers of information processing in the brain and spinal
cord, other cell types are important to mediate adequate flow of information. These include …
cord, other cell types are important to mediate adequate flow of information. These include …
[PDF][PDF] Royal Netherlands Academy of Arts and Sciences (KNAW)
F Correa-da-Silva, J Carter, XY Wang, R Sun… - Acta …, 2024 - pure.knaw.nl
Abstract Prader-Willi Syndrome (PWS) is a rare neurodevelopmental disorder of genetic
etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of …
etiology, characterized by paternal deletion of genes located at chromosome 15 in 70% of …
[HTML][HTML] Is cerebral small vessel disease a central nervous system interstitial fluidopathy?
A typical anatomical congregate and functionally distinct multicellular cerebrovascular
dynamic confer diverse blood-brain barrier (BBB) and microstructural permeabilities to …
dynamic confer diverse blood-brain barrier (BBB) and microstructural permeabilities to …