Digital twins for multiple sclerosis

I Voigt, H Inojosa, A Dillenseger, R Haase… - Frontiers in …, 2021 - frontiersin.org
An individualized innovative disease management is of great importance for people with
multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional …

Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria”

CH Polman, SC Reingold, G Edan… - Annals of Neurology …, 2005 - Wiley Online Library
New diagnostic criteria for multiple sclerosis integrating magnetic resonance image
assessment with clinical and other paraclinical methods were introduced in 2001. The …

Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria

CH Polman, SC Reingold, B Banwell… - Annals of …, 2011 - Wiley Online Library
New evidence and consensus has led to further revision of the McDonald Criteria for
diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of …

Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis

WI McDonald, A Compston, G Edan… - Annals of Neurology …, 2001 - Wiley Online Library
Abstract The International Panel on MS Diagnosis presents revised diagnostic criteria for
multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination …

Primary-progressive multiple sclerosis

DH Miller, SM Leary - The Lancet Neurology, 2007 - thelancet.com
Summary About 10–15% of patients with multiple sclerosis (MS) present with gradually
increasing neurological disability, a disorder known as primary-progressive multiple …

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time

T Kuhlmann, G Lingfeld, A Bitsch, J Schuchardt… - Brain, 2002 - academic.oup.com
Multiple sclerosis is characterized morphologically by the key features demyelination,
inflammation, gliosis and axonal damage. In recent years, it has become more evident that …

Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement

MS Freedman, EJ Thompson… - Archives of …, 2005 - jamanetwork.com
New criteria for the diagnosis of multiple sclerosis (MS) were published as the result of an
internationally formed committee. To increase the specificity of diagnosis and to minimize …

Measurement and clinical effect of grey matter pathology in multiple sclerosis

JJG Geurts, M Calabrese, E Fisher… - The Lancet …, 2012 - thelancet.com
During the past 10 years, the intense involvement of the grey matter of the CNS in the
pathology of multiple sclerosis has become evident. On gross inspection, demyelination in …

Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis

AK Hedström, I Lima Bomfim, L Barcellos… - Neurology, 2014 - AAN Enterprises
Objective: We investigated potential interactions between human leukocyte antigen (HLA)
genotype and body mass index (BMI) status in relation to the risk of developing multiple …

MRI in multiple sclerosis: current status and future prospects

R Bakshi, AJ Thompson, MA Rocca, D Pelletier… - The Lancet …, 2008 - thelancet.com
Many promising MRI approaches for research or clinical management of multiple sclerosis
(MS) have recently emerged, or are under development or refinement. Advanced MRI …