Oncolytic virotherapy
SJ Russell, KW Peng, JC Bell - Nature biotechnology, 2012 - nature.com
Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …
Normalization of the vasculature for treatment of cancer and other diseases
New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …
[HTML][HTML] A phase I/II study of triple-mutated oncolytic herpes virus G47∆ in patients with progressive glioblastoma
T Todo, Y Ino, H Ohtsu, J Shibahara… - Nature communications, 2022 - nature.com
Here, we report the results of a phase I/II, single-arm study (UMIN-CTR Clinical Trial Registry
UMIN000002661) assessing the safety (primary endpoint) of G47∆, a triple-mutated …
UMIN000002661) assessing the safety (primary endpoint) of G47∆, a triple-mutated …
[HTML][HTML] Oncolytic viruses as therapeutic cancer vaccines
DL Bartlett, Z Liu, M Sathaiah, R Ravindranathan… - Molecular cancer, 2013 - Springer
Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …
Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease
S Goel, AHK Wong, RK Jain - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Pathological angiogenesis—driven by an imbalance of pro-and antiangiogenic signaling—
is a hallmark of many diseases, both malignant and benign. Unlike in the healthy adult in …
is a hallmark of many diseases, both malignant and benign. Unlike in the healthy adult in …
Rat brain tumor models in experimental neuro-oncology: the C6, 9L, T9, RG2, F98, BT4C, RT-2 and CNS-1 gliomas
In this review we will describe eight commonly used rat brain tumor models and their
application for the development of novel therapeutic and diagnostic modalities. The C6, 9L …
application for the development of novel therapeutic and diagnostic modalities. The C6, 9L …
Systemic delivery of oncolytic viruses: hopes and hurdles
MS Ferguson, NR Lemoine, Y Wang - Advances in virology, 2012 - Wiley Online Library
Despite recent advances in both surgery and chemoradiotherapy, mortality rates for
advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one …
advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one …
[HTML][HTML] Advances and potential pitfalls of oncolytic viruses expressing immunomodulatory transgene therapy for malignant gliomas
Q Zhang, F Liu - Cell death & disease, 2020 - nature.com
Glioblastoma (GBM) is an immunosuppressive, lethal brain tumor. Despite advances in
molecular understanding and therapies, the clinical benefits have remained limited, and the …
molecular understanding and therapies, the clinical benefits have remained limited, and the …
[HTML][HTML] Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance
D Muraoka, N Seo, T Hayashi, Y Tahara… - The Journal of …, 2019 - Am Soc Clin Investig
Immune checkpoint inhibitors and adoptive transfer of gene-engineered T cells have
emerged as novel therapeutic modalities for hard-to-treat solid tumors; however, many …
emerged as novel therapeutic modalities for hard-to-treat solid tumors; however, many …
[HTML][HTML] Immune system, friend or foe of oncolytic virotherapy?
Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to
selectively infect, replicate in, and lyse malignant cells without causing harm to normal …
selectively infect, replicate in, and lyse malignant cells without causing harm to normal …