Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

Colorectal cancer (CRC) is a leading cause of death worldwide, despite progress made in
detection and management through surgery, chemotherapy, radiotherapy, and …

Progress in oncology drug development has been hampered by a lack of preclinical models
that reliably predict clinical activity of novel compounds in cancer patients. In an effort to …

Abstract The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by
genetic alterations in upstream signaling molecules such as receptor tyrosine kinases …

Over the last few decades, study of cancer in mouse models has gained popularity.
Sophisticated genetic manipulation technologies and commercialization of these murine …

Purpose: Vemurafenib, a selective inhibitor of BRAFV600, has shown significant activity in
BRAFV600 melanoma but not in less than 10% of metastatic BRAFV600 colorectal cancers …

Colorectal cancer is a serious health problem, a challenge for research, and a model for
studying the molecular mechanisms involved in its development. According to its incidence …

Abstract The PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways are two of the most
frequently dysregulated kinase cascades in human cancer. Molecular alterations in these …

Patient-derived xenograft (PDX) models are used as powerful tools for understanding
cancer biology in PDX clinical trials and co-clinical trials. In this systematic review, we focus …

Cancer frequency and prevalence have been increasing in the past decades, with
devastating impacts on patients and their families. Despite the great advances in targeted …