Mechanisms, pathophysiology and currently proposed treatments of chronic obstructive pulmonary disease

SO Rodrigues, CMC Cunha, GMV Soares, PL Silva… - Pharmaceuticals, 2021 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is one of the leading global causes of
morbidity and mortality. A hallmark of COPD is progressive airflow obstruction primarily …

Epithelial–Mesenchymal Transition Mechanisms in Chronic Airway Diseases: A Common Process to Target?

A Mottais, L Riberi, A Falco, S Soccal, S Gohy… - International journal of …, 2023 - mdpi.com
Epithelial-to-mesenchymal transition (EMT) is a reversible process, in which epithelial cells
lose their epithelial traits and acquire a mesenchymal phenotype. This transformation has …

Enhanced Keap1-Nrf2/Trx-1 axis by daphnetin protects against oxidative stress-driven hepatotoxicity via inhibiting ASK1/JNK and Txnip/NLRP3 inflammasome …

H Lv, C Zhu, W Wei, X Lv, Q Yu, X Deng, X Ci - Phytomedicine, 2020 - Elsevier
Background Oxidative stress-triggered fatal hepatotoxicity is an essential pathogenic factor
in acute liver failure (ALF). Aims To investigate the protective effect of daphnetin (Daph) on …

[HTML][HTML] The beneficial effects of antioxidants in health and diseases

S Janciauskiene - … Obstructive Pulmonary Diseases: Journal of the …, 2020 - ncbi.nlm.nih.gov
Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria,
peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure …

[HTML][HTML] Associations of ambient air pollutant exposure with seminal plasma MDA, sperm mtDNA copy number, and mtDNA integrity

G Zhang, F Jiang, Q Chen, H Yang, N Zhou… - Environment …, 2020 - Elsevier
Background Current available evidence regarding the detrimental effects of low-level
ambient air pollution on conventional semen parameters is inconclusive. In nonreproductive …

COPD lung studies of Nrf2 expression and the effects of Nrf2 activators

J Li, J Baker, A Higham, R Shah… - …, 2022 - Springer
Background Nrf2 regulates cellular antioxidant defence in lung cells, including epithelial
cells and alveolar macrophages (AM). The Nrf2/Keap-1 pathway can be modulated by …

[HTML][HTML] Therapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat

Y Liang, R Du, R Chen, PH Chu, MSM Ip… - Biomedicine & …, 2021 - Elsevier
Chronic obstructive pulmonary disease (COPD) is among the leading causes of death
worldwide, and is characterized by persistent respiratory symptoms and airflow limitation …

Therapeutic effects of black seed oil supplementation on chronic obstructive pulmonary disease patients: A randomized controlled double blind clinical trial

MA Al-Azzawi, MMN AboZaid, RAL Ibrahem, MA Sakr - Heliyon, 2020 - cell.com
This study sought to examine whether supplementation of Black Seed Oil (BSO) can
improve pulmonary function tests (PFTs), inflammation, and oxidant-antioxidant markers in …

Rieske Iron-Sulfur Protein Mediates Pulmonary Hypertension Following Nicotine/Hypoxia Coexposure

LN Truong, E Wilson Santos, YM Zheng… - American Journal of …, 2024 - atsjournals.org
The high mortality rate in patients with chronic obstructive pulmonary disease (COPD) may
be due to pulmonary hypertension (PH). These diseases are highly associated with cigarette …

Metabolomics profiling, bio-pharmaceutical properties of Hypericum lanuginosum extracts by in vitro and in silico approaches

MF Mahomoodally, G Zengin… - Industrial Crops and …, 2019 - Elsevier
Hypericum species are important as a source of natural-bioactive compounds in the Turkish
folk medicine. Among them, Hypericum lanuginosum has not been explored so far for its …