Reactive oxygen species‐(ROS‐) induced lipid peroxidation plays a critical role in cell death
including apoptosis, autophagy, and ferroptosis. This fundamental and conserved …

Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

Abstract i-Motifs are four-stranded DNA secondary structures which can form in sequences
rich in cytosine. Stabilised by acidic conditions, they are comprised of two parallel-stranded …

Occupational and environmental exposures to metals are associated with the development
of various cancers. Although carcinogenesis caused by metals has been intensively …

OBJECTIVES: The increasing incidence of nonalcoholic (NASH) and alcoholic
steatohepatitis (ASH), associated with lack of effective treatment, has prompted intensive …

Our previous studies have clearly shown that the angiogenic enzymes, matrix
metalloproteinase (MMP)‐2/9, are directly involved in human hepatic tumorigenesis and …

The human bcl-2 gene contains a GC-rich region upstream of the P1 promoter that has been
shown to be critically involved in the regulation of bcl-2 gene expression. We have …

ABSTRACT BCL2 protein functions as an inhibitor of cell apoptosis and has been found to
be aberrantly expressed in a wide range of human diseases. A highly GC-rich region …

Multiple molecular defects trigger cell death in amyotrophic lateral sclerosis (ALS). Among
these, altered transcriptional activity may perturb many cellular functions, leading to a …

Bcl-2 proteins are widely known as key controllers of mitochondrial outer membrane
permeabilization, arguably the most important step of intrinsic apoptosis. Accumulating …